Simultaneous penile prosthesis placement and collagen fleece (TachoSil) grafting. Where do we stand in 2024?
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The implantation of a three-piece inflatable penile prosthesis (IPP) has been shown to be a safe and successful treatment with a high satisfaction rate among individuals with erectile dysfunction. This narrative review aims to explore ways to improve the functional outcomes of IPP implantation. We conducted an English-language narrative review using all relevant articles sourced from PubMed. Over the years, modifications in IPP surgery have focused on increasing the longevity of prostheses and improving functional outcomes. These modifications include advancements in surgical methods, implant types, intracorporeal tubing length, the use of rear tip extenders, and reservoir placement. IPP implantation continues to significantly improve quality of life, making it essential for surgeons to stay updated on the latest developments and research to ensure the best outcomes for their patients. Optimal functional outcomes are achieved by an experienced surgical team and the use of a safe, rapid, minimally invasive surgical technique with the latest technology and equipment.
Open dataset of kinetics, kinematics, and electromyography of above-knee amputees during stand-up and sit-down
After above-knee amputation, the biological knee and ankle are replaced with prostheses. The mobility level of individuals with amputation is related, in part, to the functionality of their prostheses. To understand healthcare needs of amputees, as well as design new, more helpful prostheses, we need to understand the biomechanical effects of using current prosthetic devices. Here we present a dataset of kinetic, kinematic, electromyographic, and video recordings of nine above-knee amputees during the stand-up and sit-down movements. This dataset represents the first repository of amputee biomechanics during stand-up and sit-down with their passive, microprocessor-controlled prostheses, which are still the standard of care after above-knee amputation. The biomechanics were captured using a 12-camera motion capture system with two force plates and four EMG sensors on the intact lower limb. The dataset can serve as a reference when designing next-generation powered prostheses and controllers, to inform prosthetic prescription, and to improve amputee rehabilitation.
Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis
To investigate the anti-inflammatory effects of collagen peptides, collagen peptides from cod skin were prepared to assess their in vitro anti-inflammatory effects and in vivo efficacy against ulcerative colitis. The results show that collagen peptides demonstrated anti-inflammatory effects by inhibiting the secretion of pro-inflammatory cytokines and reducing oxidative stress in vitro. In vivo, collagen peptides significantly reduced colonic tissue damage, modulated serum cytokine balance, increased the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in colon tissue, enhanced the abundance of beneficial bacteria while reducing harmful bacteria, and restored microbial balance. In addition, collagen peptides ameliorated colitis in vivo by inhibiting the phosphorylation of NF-κB p65, IκBα and p38 MAPK in the NF-κB/MAPK signaling pathway. Based on these findings, collagen peptides could serve as potential therapeutic agents for managing ulcerative colitis.
Evolution of temporomandibular joint reconstruction: from autologous tissue transplantation to alloplastic joint replacement
The reconstruction of the temporomandibular joint presents a multifaceted clinical challenge in the realm of head and neck surgery, underscored by its relatively infrequent occurrence and the lack of comprehensive clinical guidelines. This review aims to elucidate the available approaches for TMJ reconstruction, with a particular emphasis on recent groundbreaking advancements. The current spectrum of TMJ reconstruction integrates diverse surgical techniques, such as costochondral grafting, coronoid process grafting, revascularized fibula transfer, transport distraction osteogenesis, and alloplastic TMJ replacement. Despite the available options, a singular, universally accepted ‘gold standard’ for reconstructive techniques or materials remains elusive in this field. Our review comprehensively summarizes the current available methods of TMJ reconstruction, focusing on both autologous and alloplastic prostheses. It delves into the differences of each surgical technique and outlines the implications of recent technological advances, such as 3D printing, which hold the promise of enhancing surgical precision and patient outcomes. This evolutionary progress aims not only to improve the immediate results of reconstruction but also to ensure the long-term health and functionality of the TMJ, thereby improving the quality of life for patients with end-stage TMJ disorders.
Empowering people affected by penile cancer: towards a model for supportive self-management
Improvements in the quality of penile cancer management are difficult due to the rarity of the condition and a limited evidence base for treatment decisions. Penile cancer and some of its highly morbid treatments can cause profound psychosexual and physical effects that negatively impact quality of life. Multidisciplinary interventions are required to equip patients with the support necessary to manage their emotional, physical, work, and lifestyle challenges to optimize health, well-being, and recovery. This paper outlines a model of supported self-management, which is a novel model of care for people with penile cancer to mitigate disease and treatment morbidity.
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