Lab-to-fab progress for organic photovoltaics
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Promises and challenges of indoor photovoltaics
Indoor photovoltaics (IPVs) harvest ambient light to produce electricity and can cleanly power the rapidly growing number of Internet-of-Things (IoT) sensors. The surge in IPV development, with new proposed materials, devices and products, creates the need to critically evaluate how IPV devices have advanced and to assess their prospects. In this Review, we analyse the status, challenges and opportunities of established and emerging IPV technologies, including metal-halide perovskite, organic photovoltaics, dye-sensitized solar cell and perovskite-inspired materials. Many emerging low-toxicity semiconductor materials could reach IPV efficiencies of up to 50%, but carrier localization and defect trapping hinder their performance. Wide adoption of standardized performance assessment methods is essential, and further harmonization is needed for stress tests, qualification standards and energy rating assessments. For seamless IPV integration in IoT devices, series-connected cell modules and appropriate power management hardware are crucial to maximize energy extraction. IPV device stability, technology upscaling and cost-effective integration in IoT sensors must be further developed but balanced with sustainability across the entire value chain.
A robust organic hydrogen sensor for distributed monitoring applications
Hydrogen is an abundant and clean energy source that could help to decarbonize difficult-to-electrify economic sectors. However, its safe deployment relies on the availability of cost-effective hydrogen detection technologies. We describe a hydrogen sensor that uses an organic semiconductor as the active layer. It can operate over a wide temperature and humidity range. Ambient oxygen p-dopes the organic semiconductor, which improves hole transport, and the presence of hydrogen reverses this doping process, leading to a drop in current and enabling reliable and rapid hydrogen detection. The sensor exhibits a high responsivity (more than 10,000), fast response time (less than 1 s), low limit of detection (around 192 ppb) and low power consumption (less than 2 μW). It can operate continuously for more than 646 days in ambient air at room temperature. We show that the sensor outperforms a commercial hydrogen detector in realistic sensing scenarios, illustrating its suitability for application in distributed sensor networks for early warning of hydrogen leaks and preventing explosions or fires.
Tri-specific tribodies targeting 5T4, CD3, and immune checkpoint drive stronger functional T-cell responses than combinations of antibody therapeutics
One of the most promising cancer immunotherapies is based on bi-specific T-cell engagers (BiTEs) that simultaneously bind with one arm to a tumor-associated antigen on tumor cells and with the other one to CD3 complex on T cells to form a TCR-MHC independent immune synapse. We previously generated four novel tri-specific tribodies made up of a Fab targeting 5T4, an oncofetal tumor antigen expressed on several types of tumors, a scFv targeting CD3 on T cells, and an additional scFv specific for an immune checkpoint (IC), such as PD-1, PD-L1 or LAG-3. To verify their advantages over the combinations of BiTEs (CD3/TAA) with IC inhibitors, recently used to overcome tumor immunosuppressive environment, here we tested their functional properties in comparison with clinically validated mAbs targeting the same ICs, used alone or in combination with a control bi-specific devoid of immunomodulatory scFvs, called 53 P. We found that the novel tri-specific tribodies activated human peripheral blood mononuclear cells more efficiently than clinically validated mAbs (atezolizumab, pembrolizumab, and relatlimab) either used alone or in combination with 53 P, leading to a stronger tumor cytotoxicity and cytokines release. In particular, 53L10 tribody targeting PD-L1 displayed much more potent effects than the combination of 53 P with all the clinically validated mAbs and led to complete tumor regression in vivo, showing much higher efficacy than the combination of 53 P and atezolizumab. We shed light on the molecular basis of this potentiated anti-tumor activity by evidencing that the insertion of the anti-PD-L1 moiety in 53L10 led not only to stronger binding of the tri-specific to tumor cells but also efficiently blocked the effects of increased PD-L1 on tumor cells, induced by IFNγ secretion also due to T-cell activation. These results are important also for the design of novel T-cell engagers targeting other tumor antigens.
Pilot-scale partial nitrification and anaerobic ammonium oxidation system for nitrogen removal from municipal wastewater
Partial nitrification has the advantages of saving energy and reducing the need for carbon sources in municipal wastewater treatment. However, for municipal wastewater with low ammonia, start-up and maintenance of partial nitrification is a worldwide challenge. Here we developed a pilot-scale double sludge system consisting of two sequencing batch reactors for partial nitrification (12 m2) and denitrification/anaerobic ammonium oxidation (denitrification/anammox, 8.4 m2) to treat municipal wastewater. Partial nitrification was maintained at no ammonium remaining with a nitrite accumulation rate of 87.7%. This study found that partial nitrification system effluent chemical oxygen demand increased from 24.8 mg L−1 to 64.9 mg L−1 accompanied by transformation from complete nitrification to partial nitrification. In the denitrification/anammox system, the reduction of nitrite to nitrogen required about 40% less carbon consumption than nitrate. High nitrogen removal was achieved with effluent total inorganic nitrogen of 2.7 mg L−1 without carbon addition. This work provided a pilot-scale demonstration of low-carbon high-nitrogen removal.
Anthrone/XLPE: an adaptive charge capture intelligent insulation material for advanced electric power transmission
The degradation of electrical insulation is mainly attributed to local defects. Although incorporating organic small molecules into dielectric polymers promotes the insulation strength, accurate suppression of defect development is a long-term and formidable challenge. Here we utilize the adaptive charge capture methodology to achieve precise defect suppression, leading to a 123% increase in the initiation voltage of electrical trees in anthrone/cross-linked polyethylene, significantly outperforming existing dielectric polymers and polymer composites. A significant observation is the confinement of charge at the interface between the anode and cross-linked polyethylene in anthrone/cross-linked polyethylene, generating a reverse inherent electric field near the interface and reducing the internal electric field strength of cross-linked polyethylene by up to 18%. These findings not only open avenues for further exploration of materials for ultra-high voltage cables but also play a crucial role in the commercialization and practical application of organic semiconductors in insulation dielectrics.
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