Accelerating precision oncology by converging pragmatic trials and real-world evidence
Related Articles
Human neural dynamics of real-world and imagined navigation
The ability to form episodic memories and later imagine them is integral to the human experience, influencing our recollection of the past and envisioning of the future. While rodent studies suggest the medial temporal lobe, especially the hippocampus, is involved in these functions, its role in human imagination remains uncertain. In human participants, imaginations can be explicitly instructed and reported. Here we investigate hippocampal theta oscillations during real-world and imagined navigation using motion capture and intracranial electroencephalographic recordings from individuals with chronically implanted medial temporal lobe electrodes. Our results revealed intermittent theta dynamics, particularly within the hippocampus, encoding spatial information and partitioning navigational routes into linear segments during real-world navigation. During imagined navigation, theta dynamics exhibited similar patterns despite the absence of external cues. A statistical model successfully reconstructed real-world and imagined positions, providing insights into the neural mechanisms underlying human navigation and imagination, with implications for understanding memory in real-world settings.
Cultural nuances in subtitling the religious discourse marker wallah in Jordanian drama into English
This study examines the strategies and challenges of subtitling the religious discourse marker والله wallah (by God) in Jordanian Arabic drama on Netflix. Two works, the series Jinn (2019) and the film Theeb (2014), are chosen as the corpus of the data. The study analyses the pragmatic functions of the religious marker wallah, which Arabs usually use to swear to God in different contexts and examines its English subtitles. The theoretical framework partially employs Vinay and Darbelnet’s (1995) literal translation and omission strategies and Baker’s (2018) translation approaches, including equivalence and paraphrase. A qualitative analysis is conducted to analyse the functions of occurrences of this marker in its pragmatic context, along with its subtitling into English. The study found that the religious marker is frequently omitted in the subtitles or rendered into various linguistic elements such as speech acts, intensifiers, emphatic expressions, filler words, and sarcastic utterances. wallah was either paraphrased or literally translated in some instances. The study concludes that it is necessary to employ unique techniques to overcome the cultural and linguistic gaps, depending on the function of the religious discourse marker, and to improve the reliability and quality of interpreting religious markers in audiovisual settings.
Early cardio-oncology intervention in thoracic radiotherapy: prospective single-arm pilot study
While there is increasing recognition of the morbidity of cardiovascular disease in cancer survivors, including accelerated atherosclerosis following thoracic radiotherapy, patients are frequently under-optimized for cardiovascular risk.
Multimodal insights: enhancing cultural promotion through analysis of Saudi Arabian audiovisual productions
This research explores the application of Dicerto’s (2018) multimodal pragmatic model in analyzing Arabic audiovisual productions for translation purposes, focusing on enhancing cultural promotion. Employing a qualitative descriptive analysis approach, the study examines samples from Saudi productions that promote tourism, mainly focusing on Saudi coffee and its cultural traditions to enlighten foreign visitors about Saudi culture. The analysis reveals that Dicerto’s model provides a clear framework for achieving semantic fidelity in translation, ensuring that the translated text closely resembles its original in interpretative richness. Central to this framework is the principle of optimal relevance, wherein the sender intends the message to be maximally pertinent to the audience, thereby justifying the recipient’s cognitive effort in processing it and facilitating access to the sender’s intentions. This research sheds light on the effectiveness of applying multimodal analysis models in cultural promotion efforts through audiovisual productions, particularly in Saudi Arabian tourism promotion.
Error-driven upregulation of memory representations
Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation. However, the neurophysiological mechanisms that facilitate post-error learning remain poorly understood. To address this gap, participants performed a feedback-based association learning task and a 1-back localizer task. Increased hemodynamic responses in posterior medial frontal cortex were found for internal and external origins of memory error evidence, and during post-error encoding success as quantified by subsequent recall of face-associated memories. A localizer-based machine learning model displayed a network of cognitive control regions, including posterior medial frontal and dorsolateral prefrontal cortices, whose activity was related to face-processing evidence in the fusiform face area. Representation strength was higher during failed recall and increased during encoding when subsequent recall succeeded. These data enhance our understanding of the neurophysiological mechanisms of adaptive learning by linking the need for learning with increased processing of the relevant stimulus category.
Responses