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Energy metabolism in health and diseases
Energy metabolism is indispensable for sustaining physiological functions in living organisms and assumes a pivotal role across physiological and pathological conditions. This review provides an extensive overview of advancements in energy metabolism research, elucidating critical pathways such as glycolysis, oxidative phosphorylation, fatty acid metabolism, and amino acid metabolism, along with their intricate regulatory mechanisms. The homeostatic balance of these processes is crucial; however, in pathological states such as neurodegenerative diseases, autoimmune disorders, and cancer, extensive metabolic reprogramming occurs, resulting in impaired glucose metabolism and mitochondrial dysfunction, which accelerate disease progression. Recent investigations into key regulatory pathways, including mechanistic target of rapamycin, sirtuins, and adenosine monophosphate-activated protein kinase, have considerably deepened our understanding of metabolic dysregulation and opened new avenues for therapeutic innovation. Emerging technologies, such as fluorescent probes, nano-biomaterials, and metabolomic analyses, promise substantial improvements in diagnostic precision. This review critically examines recent advancements and ongoing challenges in metabolism research, emphasizing its potential for precision diagnostics and personalized therapeutic interventions. Future studies should prioritize unraveling the regulatory mechanisms of energy metabolism and the dynamics of intercellular energy interactions. Integrating cutting-edge gene-editing technologies and multi-omics approaches, the development of multi-target pharmaceuticals in synergy with existing therapies such as immunotherapy and dietary interventions could enhance therapeutic efficacy. Personalized metabolic analysis is indispensable for crafting tailored treatment protocols, ultimately providing more accurate medical solutions for patients. This review aims to deepen the understanding and improve the application of energy metabolism to drive innovative diagnostic and therapeutic strategies.
Estimating energy consumption and GHG emissions in the U.S. food supply chain for net-zero
This work provides a database of the U.S. food system’s energy consumption and GHG emissions at the national and state levels by food supply chain (FSC) stage, fuel type, and food commodity. We estimate that the U.S. FSC consumed a total 4660 TBTU (4900 PJ) of site energy, 7130 TBTU (7500 PJ) of primary energy, and generated 970 MMT of GHG emissions in 2016. Among all the stages, on-farm production is the largest energy consumer (31% primary energy) and GHG emissions contributor (70%), largely due to raising animals. Optimizing distribution can reduce the stage’s energy consumption and GHG emissions and increase products’ shelf-life. Reducing food loss and waste is another good option, as it decreases the amount of food necessary to grow, thus impacting the overall FSC. The database can help stakeholders identify stage- and region-specific strategies and measures to curtail the environmental footprint of the U.S. food system.
Decarbonizing urban residential communities with green hydrogen systems
Community green hydrogen systems, typically consisting of rooftop photovoltaic panels paired with hybrid hydrogen-battery storage, offer urban environments with improved access to clean, on-site energy. However, economically viable pathways for deploying hydrogen storage within urban communities remain unclear. Here we develop a bottom-up energy model linking climate, human behavior and community characteristics to assess the impacts of pathways for deploying community green hydrogen systems in North America from 2030 to 2050. We show that for the same community conditions, the cost difference between the best and worst pathways can be as high as 60%. In particular, the household centralized option emerges as the preferred pathway for most communities. Furthermore, enhancing energy storage demands within these deployment pathways can reduce system design costs up to fourfold. To achieve cost-effective urban decarbonization, the study underscores the critical role of selecting the right deployment pathway and prioritizing the integration of increased energy storage in pathway designs.
Building energy savings by green roofs and cool roofs in current and future climates
The global energy demand has greatly impacted greenhouse gas emissions and climate change. Since buildings are responsible for a large portion of global energy consumption, this study investigates the energy-saving potential of green roofs and cool roofs in reducing building energy consumption. Using an integrated approach that combines climate change modeling and building energy simulation, the study evaluates these strategies in six global cities (Cairo, Hong Kong, Seoul, London, Los Angeles, and Sao Paulo) under current and future climate change scenarios. The results show that in future climates, the implementation of green and cool roofs at the city level can lead to substantial annual energy reductions, with up to 65.51% and 71.72% reduction in HVAC consumption, respectively, by 2100. These findings can guide the implementation of these strategies in different climatic zones worldwide, informing the selection and design of suitable roof mitigation strategies for specific urban contexts.
Impact of green bonds on CO2 emissions and disaggregated level renewable electricity in China and the United States of America
Green financial products have emerged that can benefit economic actors in financing green initiatives to promote renewable energy and enable carbon neutrality. Against this backdrop, the study examines the impact of green bonds (GBs) on carbon dioxide (CO2) emissions and renewable electricity generation (EG) in China and the USA, the leading countries in terms of GB issuance and CO2 emissions. To this end, the study conducts a disaggregated-level analysis by applying novel nonlinear quantile methods between January 2, 2019, and July 31, 2023. The results demonstrate that at higher quantiles; (i) GBs mainly have a dampening impact on CO2 emissions from the transportation sector in China and the USA; (ii) GBs have a stimulating impact on solar and wind EG in China; (iii) GBs have a diminishing impact on all types of EGs in the USA. Thus, GBs have an impact on carbon neutrality and renewable energy, which differs by quantiles, sectors, and EG sources. Accordingly, various policy implications are discussed in terms of further contributions of GBs to carbon neutrality and renewable energy in China and the USA.
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