Bone and muscle crosstalk in ageing and disease
Interorgan communication between bone and skeletal muscle is central to human health. A dysregulation of bone–muscle crosstalk is implicated in s…
Category: Ageing
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Ageing of the cardiovascular system is associated with frailty and various life-threatening diseases. As global populations grow older, age-related…
Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage
Female individuals who are post-menopausal present with higher incidence of knee osteoarthritis (KOA) than male counterparts; however, the mechanis…
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells
Somatic stem cell pools comprise diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative functio…