Oligodendrocyte ankyrin G in aging
Category: Ageing
Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan
Consequences of age-associated thymic atrophy include declining T-cell responsiveness to pathogens and vaccines and diminished T-cell self-toleranc…
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging
Age-related thymic involution precedes aging of all other organs in vertebrates and initiates the process of declining T cell diversity, which lead…
Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers
The early pathophysiology of Parkinson’s disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins in 51,804 UK Biobank…
A primary cilia–autophagy axis in hippocampal neurons is essential to maintain cognitive resilience
Blood-borne factors are essential to maintain neuronal synaptic plasticity and cognitive resilience throughout life. One such factor is osteocalcin…