What makes biological age epigenetic clocks tick
Category: Ageing
Single-cell transcriptomic atlas of the human testis across the reproductive lifespan
Testicular aging is associated with declining reproductive health, but the molecular mechanisms are unclear. Here we generate a dataset of 214,369 …
The complex interplay between aging and cancer
Cancer is an age-related disease, but the interplay between cancer and aging is complex and their shared molecular drivers are deeply intertwined. …
Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination
Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately r…
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan
Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of…
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease
Dystrophic neurites (also termed axonal spheroids) are found around amyloid deposits in Alzheimer’s disease (AD), where they impair axonal electr…
Post-exercise hypotension after different volumes of combined calisthenic and walking exercises in older adults with hypertension: a randomized controlled trial
This study aimed to analyze the acute effects of combined calisthenic and walking exercises using different volumes on blood pressure (BP) in aging…
Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out
Compared with teenage patients, adult patients generally show a slower rate of tooth movement and more pronounced alveolar bone loss during orthodo…