Metabolic syndrome
The metabolic syndrome (MetS) is a multiplex modifiable risk factor for cardiovascular disease, type 2 diabetes mellitus and other health outcomes,…
Category: atherosclerosis
Apolipoprotein B-containing lipoproteins in atherogenesis
Apolipoprotein B (apoB) is the main structural protein of LDLs, triglyceride-rich lipoproteins and lipoprotein(a), and is crucial for their formati…
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis
Computed tomography coronary angiography provides a non-invasive evaluation of coronary artery disease that includes phenotyping of atheroscleroti…
Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches
Atherosclerosis is a disease of large and medium arteries that can lead to life-threatening cardiovascular and cerebrovascular consequences, such a…
Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis
Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the advance of lipid-lowering therapies and anti-hypertens…
Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression
Atherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory…
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis
Beyond dyslipidemia, inflammation contributes to the development of atherosclerosis. However, intrinsic factors that counteract vascular inflammati…