Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes
Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, of…
Category: Cancer genomics
Biological correlates associated with high-risk breast cancer patients identified using a computational method
Using a novel unsupervised method to integrate multi-omic data, we previously identified a breast cancer group with a poor prognosis. In the curren…
Understanding metastasis mixed-treatment responses through genomic analyses
Early-stage and metastatic breast cancers (MBC) can exhibit genomic heterogeneity, even within the same individual. Response to therapy in metastat…
Enabling sensitive and precise detection of ctDNA through somatic copy number aberrations in breast cancer
Cell-free DNA (cfDNA) extracted from peripheral blood has emerged as a crucial biomarker source in oncology research. To enhance the detection of s…
Prognostic and molecular multi-platform analysis of CALGB 40603 (Alliance) and public triple-negative breast cancer datasets
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease that remains challenging to target with traditional therapies and t…