T cell dynamics with neoadjuvant immunotherapy in head and neck cancer
Immune-checkpoint inhibitors (ICIs) are being tested as neoadjuvant therapies in various solid tumours, including in patients with head and neck sq…
Category: Cancer genomics
Chromothripsis in cancer
Chromothripsis is a mutational phenomenon in which a single catastrophic event generates extensive rearrangements of one or a few chromosomes. This…
Decoding the functional impact of the cancer genome through protein–protein interactions
Acquisition of genomic mutations enables cancer cells to gain fitness advantages under selective pressure and, ultimately, leads to oncogenic trans…
Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection
Genomic analyses of cell-free DNA (cfDNA) in plasma are enabling noninvasive blood-based biomarker approaches to cancer detection and disease monit…