A machine learning toolkit for subtyping cancer in existing and new datasets
Category: Cancer genomics
Scalable co-sequencing of RNA and DNA from individual nuclei
The ideal technology for directly investigating the relationship between genotype and phenotype would analyze both RNA and DNA genome-wide and with…
Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases
Brain metastases frequently develop in patients with non-small cell lung cancer (NSCLC) and are a common cause of cancer-related deaths, yet our un…
Moving towards genome-wide data integration for patient stratification with Integrate Any Omics
High-throughput omics profiling advancements have greatly enhanced cancer patient stratification. However, incomplete data in multi-omics integrati…
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths
The quantification of circulating tumour DNA (ctDNA) in blood enables non-invasive surveillance of cancer progression. Here we show that a deep-lea…
Patterns and variations of copy number alterations in acute myeloid leukemia: insights from the LeukAtlas database
Recent pan-cancer analysis revealed the global pattern and potential aetiologies of copy number variation signatures in human cancers, particularly…
Cancer and disease profiles for PTEN pathogenic variants in Japanese population
A germline alteration in the PTEN gene causes a spectrum of disorders conceptualized as PTEN hamartoma tumor syndrome (PHTS), which s…
Multiomic quantification of the KRAS mutation dosage improves the preoperative prediction of survival and recurrence in patients with pancreatic ductal adenocarcinoma
Most cancer mutation profiling studies are laboratory-based and lack direct clinical application. For clinical use, it is necessary to focus on key…
EV DNA from pancreatic cancer patient-derived cells harbors molecular, coding, non-coding signatures and mutational hotspots
DNA packaged into cancer cell-derived EV is not well appreciated. Here, we uncovered signatures of EV DNA secreted by pancreatic cancer cells. The …