Fine-tuning tumor immunogenicity with mitochondrial complex I
Category: Cancer metabolism
Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma
Multiple myeloma (MM) remains an incurable hematological malignancy that necessitates the identification of novel therapeutic strategies. Here, we …
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor microenvironment (TME), whi…
Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications
Hepatocellular carcinoma features extensive metabolic reprogramming. This includes alterations in major biochemical pathways such as glycolysis, th…
Urinary metabolite model to predict the dying process in lung cancer patients
Accurately recognizing that a person may be dying is central to improving their experience of care at the end-of-life. However, predicting dying is…
Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia
Autologous T-cell therapies show limited efficacy in chronic lymphocytic leukemia (CLL), where acquired immune dysfunction prevails. In CLL, distur…
Inhibition of lanosterol synthase linking with MAPK/JNK signaling pathway suppresses endometrial cancer
Endometrial cancer (EC) is a significant health threat to women, with recurrence after treatment posing a major challenge. While abnormal cholester…