Microarray integrated spatial transcriptomics (MIST) for affordable and robust digital pathology
10X Visium, a popular Spatial transcriptomics (ST) method, faces limited adoption due to its high cost and restricted sample usage per slide. To ad…
Category: Computational biology and bioinformatics
Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma
Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin lymphomas caused by malignant T cells which migrate to the skin and lead to rash-like lesions wh…
Splicing junction-based classifier for the detection of abnormal constitutive activation of the KEAP1-NRF2 system
The KEAP1-NRF2 system plays a crucial role in responding to oxidative and electrophilic stress. Its dysregulation can cause the overexpression of d…
Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer
Dysregulated pH is now recognised as a hallmark of cancer. Recent evidence has revealed that the endosomal pH regulator Na+/H+
Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer
Understanding transcriptional heterogeneity in cancer cells and its implication for treatment response is critical to identify how resistance occur…
Modeling critical dosing strategies for stromal-induced resistance to cancer therapy
Complex interactions between stromal cells, tumor cells and therapies can influence environmental factors that in turn impact anticancer treatment …
A single-cell network approach to decode metabolic regulation in gynecologic and breast cancers
Cancer metabolism is characterized by significant heterogeneity, presenting challenges for treatment efficacy and patient outcomes. Understanding t…
The transcriptomic architecture of common cancers reflects synthetic lethal interactions
To maintain cell fitness, deleterious genetic alterations are buffered by compensatory changes in additional genes. In cancer, buffering processes …