Systemic capillary leak syndrome
The vascular endothelial barrier maintains intravascular volume and metabolic homeostasis. Although plasma fluids and proteins extravasate continuo…
Category: Cardiovascular diseases
Hereditary haemorrhagic telangiectasia
Hereditary haemorrhagic telangiectasia (HHT) is a vascular dysplasia inherited as an autosomal dominant trait and caused by loss-of-function pathog…
Functional diversity of cardiac macrophages in health and disease
Macrophages make up a substantial portion of the stromal compartment of the heart in health and disease. In the past decade, the origins of these c…
Endomyocardial fibrosis: recent advances and future therapeutic targets
Endomyocardial fibrosis, first described >75 years ago, is a cause of restrictive cardiomyopathy with an unclear aetiopathogenesis that is most …
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies
Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions of coding and noncoding rare variants to com…
The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination
Myocarditis, characterized by inflammatory cell infiltration, can have multiple etiologies, including severe acute respiratory syndrome coronavirus…