The study that pioneered islet isolation techniques
Category: Cell biology
Chromosomal inversion at the DG1 promoter drives double-grain spikelets and enhances grain yield in sorghum
The phenomenon of multiple-grain spikelets is frequently observed in gramineous crops. In the case of dual-floret spikelets, the upper fertile flor…
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
A comprehensive understanding of the evolution of the immune landscape in humans across the entire lifespan at single-cell transcriptional and prot…
Biases in machine-learning models of human single-cell data
Recent machine-learning (ML)-based advances in single-cell data science have enabled the stratification of human tissue donors at single-cell resol…
Mitochondrial genetics, signalling and stress responses
Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study …
The reverse transcriptase domain of prime editors contributes to DNA repair in mammalian cells
Reverse transcriptase (RT) has been shown to play a role in double-strand break repair in bacteria, yet the impact of the RT component of prime edi…
Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data
High-dimensional multiplexed imaging can reveal the spatial organization of tumour tissues at the molecular level. However, owing to the scale and …