Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload
Sodium influx and overload are frequently observed in human tissue injuries. Whether sodium overload imposes a causative effect on necrotic cell de…
Category: Cell death
RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease
The emerging field of epitranscriptomics is reshaping our understanding of post-transcriptional gene regulation in inflammatory diseases. N<…
Cathepsin B prevents cell death by fragmentation and destruction of pathological amyloid fibrils
Amyloid fibrils cause organ and tissue dysfunction in numerous severe diseases. Despite the prevalence and severity of amyloidoses, there is still …
CeDaD—a novel assay for simultaneous tracking of cell death and division in a single population
The cell division cycle and the various forms of programmed cell death are interconnected. A prominent example is the tumor suppressor p53, which n…
Different types of cell death and their interactions in myocardial ischemia–reperfusion injury
Myocardial ischemia–reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow is resto…
Targeting Chk1 and Wee1 kinases enhances radiosensitivity of 2D and 3D head and neck cancer models to X-rays and low/high-LET protons
Ionising radiation causes the introduction of DNA damage, more specifically double strand breaks (DSBs) and complex DNA damage (CDD), that induces …