Characterization of senescence and nuclear reorganization in aging gingival cells
Cellular senescence is a stress response that limits tumor formation by promoting the removal of damaged cells through the immune system. In this s…
Category: Cell signalling
Integrins in the kidney — beyond the matrix
The development and proper functioning of the kidney is dependent on the interaction of kidney cells with the surrounding extracellular matrix (ECM…
Protein handling in kidney tubules
The kidney proximal tubule reabsorbs and degrades filtered plasma proteins to reclaim valuable nutrients and maintain body homeostasis. Defects in …
Modes of Notch signalling in development and disease
Many different animal developmental and homeostatic processes rely on signalling via the highly conserved Notch pathway. Often Notch signalling has…
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Macrophages stimulated by lipopolysaccharide (LPS) generate mitochondria-derived reactive oxygen species (mtROS) that act as antimicrobial agents a…