Why loneliness requires a multidimensional approach: a critical narrative review
An immense corpus of work documents deleterious effects of loneliness on physical health, cognition, psychological symptoms, and wellbeing. In this…
Category: depression
Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression
Deciphering the genetic architecture of depression is pivotal for characterizing the associated pathophysiological processes and development of new…
Major depressive disorder on a neuromorphic continuum
The heterogeneity of major depressive disorder (MDD) has hindered clinical translation and neuromarker identification. Biotyping facilitates solvin…
The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study
Late-life depression (LLD) has been linked to increased likelihood of dementia, although mechanisms responsible for this association remain largely…
Preventing psychosis in people at clinical high risk: an updated meta-analysis by the World Psychiatric Association Preventive Psychiatry section
Recently published large-scale randomised controlled trials (RCTs) have questioned the efficacy of preventive interventions in individuals at clini…
Genome-wide analysis identifies novel shared loci between depression and white matter microstructure
Depression, a complex and heritable psychiatric disorder, is associated with alterations in white matter microstructure, yet their shared genetic b…
Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain
Chronic stress is a causal antecedent condition for major depressive disorder and associates with altered patterns of neural connectivity. There ar…
A network analysis of postpartum depression and mother-to-infant bonding shows common and unique symptom-level connections across three postpartum periods
Postpartum depression and mother-to-infant bonding difficulties (MIBD), two issues crucial to maternal and infant mental health, often coexist and …
Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p
Obesity increases the risk of depression. Evidence shows that peripheral inflammation, glycemic dysregulation, and hyperactivity within the hypotha…