Progress in understanding the vertebrate segmentation clock
The segmentation clock is a molecular oscillator that regulates the periodic formation of somites from the presomitic mesoderm during vertebrate em…
Category: Development
PDGFRA is a conserved HAND2 effector during early cardiac development
The basic helix–loop–helix transcription factor HAND2 has multiple roles during vertebrate organogenesis, including cardiogenesis. However, muc…
Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis
Sex determination and differentiation in zebrafish involve a complex interaction of male and female-promoting factors. While Dmrt1 has been establi…
Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53
Germline inactivating mutations of the SLC25A1 gene contribute to various human disorders, including Velocardiofacial (VCFS), DiGeorge (DGS)…
Distinct developmental outcomes in DNA repair-deficient FANCC c.67delG mutant and FANCC−/− Mice
Fanconi Anemia (FA) is an autosomal recessive disorder characterized by diverse clinical manifestations such as aplastic anemia, cancer predisposit…