The design and engineering of synthetic genomes
Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect fundamental questions of genome function and to engineer…
Category: Genetic engineering
Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs
Hemophilia A (HA) is caused by mutations in coagulation factor VIII (FVIII). Genome editing in conjunction with patient-derived induc…
One-step Cre-loxP organism creation by TAx9
The creation of organisms with Cre-loxP conditional gene recombination systems often faces challenges, particularly when creating the initia…