Plasma proteome variation and its genetic determinants in children and adolescents
Our current understanding of the determinants of plasma proteome variation during pediatric development remains incomplete. Here, we show that gene…
Category: Genome-wide association studies
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventric…
Family-based genome-wide association study designs for increased power and robustness
Family-based genome-wide association studies (FGWASs) use random, within-family genetic variation to remove confounding from estimates of direct ge…
An enhanced framework for local genetic correlation analysis
Genetic correlation is a key parameter in the joint genetic model of complex traits, but it is usually estimated on a global genomic scale. Underst…
Healthy lifestyle practice correlates with decreased obesity prevalence in individuals with high polygenic risk: TMM CommCohort study
Obesity and overweight, fundamental components of the metabolic syndrome, predispose individuals to lifestyle-related diseases. The extent to which…
Investigating mobile element variations by statistical genetics
The integration of structural variations (SVs) in statistical genetics provides an opportunity to understand the genetic factors influencing comple…