Regulation of cGAS–STING signalling and its diversity of cellular outcomes
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling pathway, which recognizes both pathogen DNA and host-deriv…
Category: Innate immunity
Targeting the mosquito prefoldin–chaperonin complex blocks Plasmodium transmission
The Plasmodium infection cycle in mosquitoes relies on numerous host factors in the vector midgut, which can be targeted with therapeutics. …
Interactions between gut microbes and host cells control gut barrier and metabolism
Gut microbes are now considered as key partners involved in human physiology. Data have shown that microbes contribute to regulate energy, lipid, a…
The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation
The skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmenta…
Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
Immunometabolism is critical in the regulation of immunity and inflammation; however, the mechanism of preventing aberrant activation-induced immun…