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Enantioselective synthesis of chiroplasmonic helicoidal nanoparticles by nanoconfinement in chiral dielectric shells

Helicoid metal nanoparticles with intrinsic chirality have unveiled tailorable properties and unlocked many chirality-related applications across various fields. Nevertheless, the existing strategies for enantioselective synthesis of helicoid metal nanoparticles have been predominantly limited to gold. Here, we demonstrate a robust and versatile strategy for the enantioselective synthesis of helicoid nanoparticles beyond gold, leveraging chiral nanoconfinement provided by chiral SiO2 or nanoshells. The chiral nanoconfinement strategy enables the decoupling of ligand-directed crystal growth from chiral induction, allowing for the independent tuning of these two critical aspects. As a result, this approach can not only facilitate the replication of chiral shapes from the chiral nanoshells but also allow the generation of alternative chiral shapes. By employing this approach, we demonstrate the enantioselective synthesis of helicoid Pt, Au@Pt, Au@Pd, Au@Ag, and Au@Cu nanoparticles. The chiroplasmonic properties of Pt- and Pd-based chiral nanoparticles have been discovered, and the inversion of chiroplasmonic properties of Ag-based chiral nanoparticles via facet control has been documented and theoretically explained. The chiral nanoconfinement strategy enriches the toolbox for creating chiral nanoparticles and supports their exploration in diverse applications.

Optical sorting: past, present and future

Optical sorting combines optical tweezers with diverse techniques, including optical spectrum, artificial intelligence (AI) and immunoassay, to endow unprecedented capabilities in particle sorting. In comparison to other methods such as microfluidics, acoustics and electrophoresis, optical sorting offers appreciable advantages in nanoscale precision, high resolution, non-invasiveness, and is becoming increasingly indispensable in fields of biophysics, chemistry, and materials science. This review aims to offer a comprehensive overview of the history, development, and perspectives of various optical sorting techniques, categorised as passive and active sorting methods. To begin, we elucidate the fundamental physics and attributes of both conventional and exotic optical forces. We then explore sorting capabilities of active optical sorting, which fuses optical tweezers with a diversity of techniques, including Raman spectroscopy and machine learning. Afterwards, we reveal the essential roles played by deterministic light fields, configured with lens systems or metasurfaces, in the passive sorting of particles based on their varying sizes and shapes, sorting resolutions and speeds. We conclude with our vision of the most promising and futuristic directions, including AI-facilitated ultrafast and bio-morphology-selective sorting. It can be envisioned that optical sorting will inevitably become a revolutionary tool in scientific research and practical biomedical applications.

Edge states with hidden topology in spinner lattices

Symmetries – whether explicit, latent, or hidden – are fundamental to understanding topological materials. This work introduces a prototypical spring-mass model that extends beyond established canonical models, revealing topological edge states with distinct profiles at opposite edges. These edge states originate from hidden symmetries that become apparent only in deformation coordinates, as opposed to the conventional displacement coordinates used for bulk-boundary correspondence. Our model, realized through the intricate connectivity of a spinner chain, demonstrates experimentally distinct edge states at opposite ends. By extending this framework to two dimensions, we explore the conditions required for such edge waves and their hidden symmetry in deformation coordinates. We also show that these edge states are robust against disorders that respect the hidden symmetry. This research paves the way for advanced material designs with tailored boundary conditions and edge state profiles, offering potential applications in fields such as photonics, acoustics, and mechanical metamaterials.

Dynamical topology of chiral and nonreciprocal state transfers in a non-Hermitian quantum system

Topological phenomena are fundamentally underlain by the geometric phase of eigenstates. Time-varying Hamiltonians furthermore allow for a dynamical topological invariant associated with continuous flows. We study chiral and nonreciprocal dynamics by encircling the exceptional points (EPs) of non-Hermitian Hamiltonians in a trapped ion system. We find that these dynamics are topologically robust against external perturbations even in the presence of dissipation-induced nonadiabatic transitions. Furthermore, our results indicate that these behaviors are protected by dynamical vorticity—an emerging topological invariant associated with the energy dispersion of non-Hermitian band structures in a parallel transported eigenbasis. Through the quantum state tomography, the symmetry breaking and other key features of topological dynamics are directly verified. These results mark a significant step towards exploring topological properties of open quantum systems.

Genome-wide analysis identifies novel shared loci between depression and white matter microstructure

Depression, a complex and heritable psychiatric disorder, is associated with alterations in white matter microstructure, yet their shared genetic basis remains largely unclear. Utilizing the largest available genome-wide association study (GWAS) datasets for depression (N = 674,452) and white matter microstructure (N = 33,224), assessed through diffusion tensor imaging metrics such as fractional anisotropy (FA) and mean diffusivity (MD), we employed linkage disequilibrium score regression method to estimate global genetic correlations, local analysis of [co]variant association approach to pinpoint genomic regions with local genetic correlations, and conjunctional false discovery rate analysis to identify shared variants. Our findings revealed that depression showed significant local genetic correlations with FA in 37 genomic regions and with MD in 59 regions, while global genetic correlations were weak. Variant-level analysis identified 78 distinct loci jointly associated with depression (25 novel loci) and FA (35 novel loci), and 41 distinct loci associated with depression (17 novel loci) and MD (25 novel loci). Further analyses showed that these shared loci exhibited both concordant and discordant effect directions between depression and white matter traits, as well as distinct yet overlapping hemispheric patterns in their genetic architecture. Enrichment analysis of these shared loci implicated biological processes related to metabolism and regulation. This study provides evidence of a mixed-direction shared genetic architecture between depression and white matter microstructure. The identification of specific loci and pathways offers potential insights for developing targeted interventions to improve white matter integrity and alleviate depressive symptoms.

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