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Estimated human intake of endogenous and exogenous hormones from beef in the United States
Endogenous and exogenous hormones may be present in beef. Human consumption of hormones has been linked to adverse health effects.
Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation
The hippocampus (HPC) has emerged as a critical player in the control of food intake, beyond its well-known role in memory. While previous studies have primarily associated the HPC with food intake inhibition, recent research suggests a role in appetitive processes. Here we identified spatially distinct neuronal populations within the dorsal HPC (dHPC) that respond to either fats or sugars, potent natural reinforcers that contribute to obesity development. Using activity-dependent genetic capture of nutrient-responsive dHPC neurons, we demonstrate a causal role of both populations in promoting nutrient-specific intake through different mechanisms. Sugar-responsive neurons encoded spatial memory for sugar location, whereas fat-responsive neurons selectively enhanced the preference and motivation for fat intake. Importantly, stimulation of either nutrient-responsive dHPC neurons increased food intake, while ablation differentially impacted obesogenic diet consumption and prevented diet-induced weight gain. Collectively, these findings uncover previously unknown orexigenic circuits underlying macronutrient-specific consumption and provide a foundation for developing potential obesity treatments.
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism
Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2. In the current study, we found that the depletion of Ntsr2 in white adipocytes upregulated food intake, while the local treatment of NTS suppressed food intake. Our mechanistic study revealed that suppression of NTS-NTSR2 signaling enhanced the phosphorylation of ceramide synthetase 2, increased the abundance of its products ceramides C20–C24, and downregulated the production of GDF15 in white adipose tissues, which was responsible for the elevation of food intake. We discovered a potential causal and positive correlation between serum C20–C24 ceramide levels and human food intake in four populations with different ages and ethnic backgrounds. Together, our study shows that NTS-NTSR2 signaling in white adipocytes can regulate food intake via its direct control of lipid metabolism and production of GDF15. The ceramides C20–C24 are key factors regulating food intake in mammals.
State-level policies alone are insufficient to meet the federal food waste reduction goal in the United States
The United States Food Loss and Waste Reduction Goal seeks to reduce national food waste by 50%, down to 74 kg per capita, by 2030. Here we investigate state policies’ alignment with the federal goal across four policy categories. We develop a policy scoring matrix and apply it to wasted food solutions listed in the non-profit ReFED’s database to derive ranges of food waste diversion potential and projected generation across states. On the basis of state policies alone, no state can meet the federal target. We estimated a diversion potential of 5–14 kg per capita and a food waste generation of 149 kg per capita nationally in 2022, equivalent to the 2016 baseline. Without additional intervention at the state and federal level promoting a shift from food waste recycling towards prevention, rescue and repurposing, food generation in the United States will probably remain high.
Quantifying vitamin D intake among Aboriginal and Torres Strait Islander peoples in Australia
Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] concentration < 50 nmol/L) is prevalent among Aboriginal and Torres Strait Islander peoples in Australia. Alternative to sun exposure (the primary source of vitamin D), vitamin D can also be obtained from food (e.g. fish, eggs, and meat) and supplements. However, the vitamin D intake of this population group is unknown. We aimed to provide the first quantification of vitamin D intake using nationally representative data from Aboriginal and Torres Strait Islander peoples.
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