Occupational dust and chemical exposures and the development of autoimmune rheumatic diseases
Related Articles
Anthropogenic sulfate-climate interactions suppress dust activity over East Asia
Observational evidences indicate a significant decline in dust storm frequencies over the East Asian arid-semiarid region during recent decades, which creates a strong contrast with a great increase in sulfate emissions over monsoonal Asia. However, the causes for decline of dust activities are still controversial. Through conducting a set of idealized sensitivity experiments of regional aerosol perturbations, here we show that anthropogenic sulfate aerosols over monsoonal Asia remarkably suppress the regional dust activities over East Asia. Southward shift of Asian westerly jet stream induced by sulfate aerosols results in increasing precipitation and weakening surface wind speeds over the arid-semiarid region, thereby suppressing local dust emission fluxes. Further, the latest Sixth Coupled Model Intercomparison Project simulations indicate that anthropogenic aerosols partly drive the recent weakening in regional dust activities and that future change of regional dust activities will likely depend on emissions scenarios of Asian anthropogenic aerosols and greenhouse gases.
Mass and particle size distribution of household dust on children’s hands
Children are vulnerable to household dust exposure; however, to date, a handful of studies simultaneously report both the mass and particle size of household dust found on children’s hands after natural indoor play activities.
Energy metabolism in health and diseases
Energy metabolism is indispensable for sustaining physiological functions in living organisms and assumes a pivotal role across physiological and pathological conditions. This review provides an extensive overview of advancements in energy metabolism research, elucidating critical pathways such as glycolysis, oxidative phosphorylation, fatty acid metabolism, and amino acid metabolism, along with their intricate regulatory mechanisms. The homeostatic balance of these processes is crucial; however, in pathological states such as neurodegenerative diseases, autoimmune disorders, and cancer, extensive metabolic reprogramming occurs, resulting in impaired glucose metabolism and mitochondrial dysfunction, which accelerate disease progression. Recent investigations into key regulatory pathways, including mechanistic target of rapamycin, sirtuins, and adenosine monophosphate-activated protein kinase, have considerably deepened our understanding of metabolic dysregulation and opened new avenues for therapeutic innovation. Emerging technologies, such as fluorescent probes, nano-biomaterials, and metabolomic analyses, promise substantial improvements in diagnostic precision. This review critically examines recent advancements and ongoing challenges in metabolism research, emphasizing its potential for precision diagnostics and personalized therapeutic interventions. Future studies should prioritize unraveling the regulatory mechanisms of energy metabolism and the dynamics of intercellular energy interactions. Integrating cutting-edge gene-editing technologies and multi-omics approaches, the development of multi-target pharmaceuticals in synergy with existing therapies such as immunotherapy and dietary interventions could enhance therapeutic efficacy. Personalized metabolic analysis is indispensable for crafting tailored treatment protocols, ultimately providing more accurate medical solutions for patients. This review aims to deepen the understanding and improve the application of energy metabolism to drive innovative diagnostic and therapeutic strategies.
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in immune defense, surveillance, and homeostasis. This review systematically discusses the types of hematopoietic progenitors that give rise to macrophages, including primitive hematopoietic progenitors, erythro-myeloid progenitors, and hematopoietic stem cells. These progenitors have distinct genetic backgrounds and developmental processes. Accordingly, macrophages exhibit complex and diverse functions in the body, including phagocytosis and clearance of cellular debris, antigen presentation, and immune response, regulation of inflammation and cytokine production, tissue remodeling and repair, and multi-level regulatory signaling pathways/crosstalk involved in homeostasis and physiology. Besides, tumor-associated macrophages are a key component of the TME, exhibiting both anti-tumor and pro-tumor properties. Furthermore, the functional status of macrophages is closely linked to the development of various diseases, including cancer, autoimmune disorders, cardiovascular disease, neurodegenerative diseases, metabolic conditions, and trauma. Targeting macrophages has emerged as a promising therapeutic strategy in these contexts. Clinical trials of macrophage-based targeted drugs, macrophage-based immunotherapies, and nanoparticle-based therapy were comprehensively summarized. Potential challenges and future directions in targeting macrophages have also been discussed. Overall, our review highlights the significance of this versatile immune cell in human health and disease, which is expected to inform future research and clinical practice.
Observationally derived magnetic field strength and 3D components in the HD 142527 disk
The magnetic fields in protoplanetary disks around young stars play an important role in disk evolution and planet formation. Measuring the polarized thermal emission from magnetically aligned grains is a reliable method for tracing magnetic fields. However, it has been difficult to observe magnetic fields from dust polarization in protoplanetary disks because other polarization mechanisms involving grown dust grains become efficient. Here we report multi-wavelength (0.87, 1.3, 2.1 and 2.7 mm) observations of polarized thermal emission in the protoplanetary disk around HD 142527, which shows a lopsided dust distribution. We revealed that smaller dust particles still exhibit magnetic alignment in the southern part of the disk. Furthermore, angular offsets between the observed magnetic field and the disk azimuthal direction were discovered. These offsets can be used to measure the relative strengths of each component of a three-dimensional magnetic field (radial (Br), azimuthal (Bϕ) and vertical (Bz)). Applying this method, we derived the magnetic field around a 200 au radius from the protostar as ∣Br∣:∣Bϕ∣:∣Bz∣ ≈ 0.26:1:0.23 with a strength of ~0.3 mG. Our observations provide some key parameters of magnetic activities, including the plasma beta, which has had to be assumed in theoretical studies. In addition, the radial and vertical angular momentum transfers were found to be comparable, which poses a challenge to theoretical studies of protoplanetary disks.
Responses