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Optical sorting: past, present and future

Optical sorting combines optical tweezers with diverse techniques, including optical spectrum, artificial intelligence (AI) and immunoassay, to endow unprecedented capabilities in particle sorting. In comparison to other methods such as microfluidics, acoustics and electrophoresis, optical sorting offers appreciable advantages in nanoscale precision, high resolution, non-invasiveness, and is becoming increasingly indispensable in fields of biophysics, chemistry, and materials science. This review aims to offer a comprehensive overview of the history, development, and perspectives of various optical sorting techniques, categorised as passive and active sorting methods. To begin, we elucidate the fundamental physics and attributes of both conventional and exotic optical forces. We then explore sorting capabilities of active optical sorting, which fuses optical tweezers with a diversity of techniques, including Raman spectroscopy and machine learning. Afterwards, we reveal the essential roles played by deterministic light fields, configured with lens systems or metasurfaces, in the passive sorting of particles based on their varying sizes and shapes, sorting resolutions and speeds. We conclude with our vision of the most promising and futuristic directions, including AI-facilitated ultrafast and bio-morphology-selective sorting. It can be envisioned that optical sorting will inevitably become a revolutionary tool in scientific research and practical biomedical applications.

Airborne optical imaging technology: a road map in CIOMP

Airborne optical imaging can flexibly obtain the intuitive information of the observed scene from the air, which plays an important role of modern optical remote sensing technology. Higher resolution, longer imaging distance, and broader coverage are the unwavering pursuits in this research field. Nevertheless, the imaging environment during aerial flights brings about multi-source dynamic interferences such as temperature, air pressure, and complex movements, which forms a serious contradiction with the requirements of precision and relative staticity in optical imaging. As the birthplace of Chinese optical industry, the Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP) has conducted the research on airborne optical imaging for decades, resulting in rich innovative achievements, completed research conditions, and exploring a feasible development path. This article provides an overview of the innovative work of CIOMP in the field of airborne optical imaging, sorts out the milestone nodes, and predicts the future development direction of this discipline, with the aim of providing inspiration for related research.

All-optical superconducting qubit readout

The rapid development of superconducting quantum hardware is expected to run into substantial restrictions on scalability because error correction in a cryogenic environment has stringent input–output requirements. Classical data centres rely on fibre-optic interconnects to remove similar networking bottlenecks. In the same spirit, ultracold electro-optic links have been proposed and used to generate qubit control signals, or to replace cryogenic readout electronics. So far, these approaches have suffered from either low efficiency, low bandwidth or additional noise. Here we realize radio-over-fibre qubit readout at millikelvin temperatures. We use one device to simultaneously perform upconversion and downconversion between microwave and optical frequencies and so do not require any active or passive cryogenic microwave equipment. We demonstrate all-optical single-shot readout in a circulator-free readout scheme. Importantly, we do not observe any direct radiation impact on the qubit state, despite the absence of shielding elements. This compatibility between superconducting circuits and telecom-wavelength light is not only a prerequisite to establish modular quantum networks, but it is also relevant for multiplexed readout of superconducting photon detectors and classical superconducting logic.

Metasurface enabled high-order differentiator

Metasurface-enabled optical analog differentiation has garnered significant attention due to its inherent capacity of parallel operation, compactness, and low power consumption. Most previous works focused on the first- and second-order operations, while several significant works have also achieved higher-order differentiation in both real space and k-space. However, how to construct the desired optical transfer function in a practical system to realize scalable and multi-order-parallel high-order differentiation of images in real space, and particularly how to leverage it to tackle practical problems, have not been fully explored. Here, drawing on the basic mathematical feature of the Fourier transform, we theoretically propose universal phase-gradient functions of the Pancharatnam-Berry-phase-based meta-device for performing arbitrary order differentiation. The fifth-order optical differentiations for both intensity and phase images are realized in the experiment. More importantly, by exploring this elaborately designed spatial differentiator, we construct another scheme for optical super-resolution and achieve the estimation of the distance between two incoherent point sources within 0.015 of the Rayleigh distance, which thereby provides a potential toolkit for optical alignment in high-precision semiconductor nano-fabrication. Our findings hold promise for image processing, microscopy imaging, and optical super-resolution imaging.

Innovating beyond electrophysiology through multimodal neural interfaces

Neural circuits distributed across different brain regions mediate how neural information is processed and integrated, resulting in complex cognitive capabilities and behaviour. To understand dynamics and interactions of neural circuits, it is crucial to capture the complete spectrum of neural activity, ranging from the fast action potentials of individual neurons to the population dynamics driven by slow brain-wide oscillations. In this Review, we discuss how advances in electrical and optical recording technologies, coupled with the emergence of machine learning methodologies, present a unique opportunity to unravel the complex dynamics of the brain. Although great progress has been made in both electrical and optical neural recording technologies, these alone fail to provide a comprehensive picture of the neuronal activity with high spatiotemporal resolution. To address this challenge, multimodal experiments integrating the complementary advantages of different techniques hold great promise. However, they are still hindered by the absence of multimodal data analysis methods capable of providing unified and interpretable explanations of the complex neural dynamics distinctly encoded in these modalities. Combining multimodal studies with advanced data analysis methods will offer novel perspectives to address unresolved questions in basic neuroscience and to develop treatments for various neurological disorders.

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