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An umbrella review of health outcomes following traumatic brain injury
While numerous reviews have assessed the association between traumatic brain injury (TBI) and various mental and physical health outcomes, a comprehensive evaluation of the scope, validity, and quality of evidence is lacking. Here we present an umbrella review of a wide range of health outcomes following TBI and outline outcome risks across subpopulations. On 17 May 2023, we searched Embase, Medline, Global Health, PsycINFO, and Cochrane Database of Systematic Reviews for systematic reviews and meta-analyses. We compared risk ratios across different outcomes for risks compared with people without TBI and examined study quality, including heterogeneity, publication bias, and prediction intervals. The study was registered with PROSPERO (CRD42023432255). We identified 24 systematic reviews and meta-analyses covering 24 health outcomes in 31,397,958 participants. The current evidence base indicates an increased risk of multiple mental and physical health outcomes, including psychotic disorders, attention-deficit/hyperactivity disorder, suicide, and depression. Three outcomes—dementia, violence perpetration, and amyotrophic lateral sclerosis—had meta-analytical evidence of at least moderate quality, which suggest targets for more personalized assessment. Health-care services should review how to prevent adverse long-term outcomes in TBI.
Treatment modalities for patients with Persistent Spinal Pain Syndrome Type II: A systematic review and network meta-analysis
Appropriate management of patients with Persistent Spinal Pain Syndrome Type 2 (PSPS-T2) remains challenging. The need for robust evidence for treatment modalities is urgently pressing. The aim of this systematic review and network meta-analysis (NMA) is to compare different treatment modalities for patients with PSPS-T2 on pain intensity.
The influence of the gingival phenotype on implant survival rate and clinical parameters: a systematic review
The goal of this systematic review was to verify whether the gingival phenotype (thick or thin) could impact the dental implant survival rate by affecting the marginal bone.
How Shakespeare’s works have been reinterpreted, adapted and reshaped: a bibliometric review and trend analysis of Shakespeare studies from 2000 to 2023
Since transitioning into the post-theory era in 2000, Shakespearean studies have increasingly attracted interdisciplinary attention, engaging fields such as literature, performance studies, digital humanities, and cultural studies. Despite this broad interest, the discipline often lacks a cohesive framework to integrate these perspectives effectively. This study addresses this issue by applying bibliometric methods to data from the Web of Science Core Collection, using tools like VOSViewer and CiteSpace for analysis and visualization. By examining how Shakespeare’s works have been reinterpreted and adapted across diverse cultural and temporal contexts, the research employs the TCCM (Theory, Context, Characteristic, Methodology) framework to analyze thematic developments and interdisciplinary scope in Shakespeare studies from 2000 to 2023. Key findings reveal recurring research themes, including canonical text analysis, gender and performance, cross-cultural dissemination, adaptation, and the growing influence of digital humanities. The study identifies four distinct phases in the evolution of the field: the Initial Phase (2000–2005), focused on textual authenticity and literary value; the Transition Phase (2005–2010), marked by the integration of cultural studies and gender theory; the Mature Phase (2010–2019), exploring societal issues such as ethics and environmental humanities; and the Post-Pandemic Phase (2019–2023), emphasizing globalization and environmental concerns. These phases reflect shifts in academic priorities, methodologies, and interdisciplinary approaches, demonstrating the field’s responsiveness to global and technological developments. This study highlights the importance of deepening interdisciplinary integration and adopting emerging frameworks, such as new materialism, while combining distant and close reading techniques. These approaches offer a nuanced understanding of Shakespeare’s works, showcasing their enduring relevance and cultural transformation in a globalized and rapidly evolving academic landscape.
GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment
The presence of a positive deep surgical margin in tongue squamous cell carcinoma (TSCC) significantly elevates the risk of local recurrence. Therefore, a prompt and precise intraoperative assessment of margin status is imperative to ensure thorough tumor resection. In this study, we integrate Raman imaging technology with an artificial intelligence (AI) generative model, proposing an innovative approach for intraoperative margin status diagnosis. This method utilizes Raman imaging to swiftly and non-invasively capture tissue Raman images, which are then transformed into hematoxylin-eosin (H&E)-stained histopathological images using an AI generative model for histopathological diagnosis. The generated H&E-stained images clearly illustrate the tissue’s pathological conditions. Independently reviewed by three pathologists, the overall diagnostic accuracy for distinguishing between tumor tissue and normal muscle tissue reaches 86.7%. Notably, it outperforms current clinical practices, especially in TSCC with positive lymph node metastasis or moderately differentiated grades. This advancement highlights the potential of AI-enhanced Raman imaging to significantly improve intraoperative assessments and surgical margin evaluations, promising a versatile diagnostic tool beyond TSCC.
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