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An axis-specific mitral annuloplasty ring eliminates mitral regurgitation allowing mitral annular motion in an ovine model

Current mitral annuloplasty rings fail to restrict the anteroposterior distance while allowing dynamic mitral annular changes. We designed and manufactured a mitral annuloplasty ring that demonstrated axis-specific, selective flexibility to meet this clinical need. The objectives were to evaluate ex vivo biomechanics of this ring and to validate the annular dynamics and safety after ring implantation in vivo.

Drivers of mesoscale convective aggregation and spatial humidity variability in the tropical western Pacific

We examine mesoscale convective organisation in the tropical western Pacific using a multivariate analysis of column humidity, precipitation and sea surface temperature (SST) observations. We demonstrate that in boreal summer and autumn, convection remains spatially random despite radiative-feedbacks acting to aggregate convection, which we attribute to the high density of convective moisture sources and the role of wind shear. Instead, in winter and spring, a weak meridional SST gradient exists and convection is usually clustered over the regions of warmer SSTs, with significant meridional humidity gradients. However, this is sporadically interrupted by episodes of convection migration to the coldest SSTs and limited spatial humidity variance. These episodes are the result of westward propagating equatorial waves, which remove meridional humidity gradients. It appears that the drivers of mesoscale convective clustering and humidity variability in the Pacific warm pool are the SST gradients, shear, and equatorial wave dynamics.

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