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Latent circuit inference from heterogeneous neural responses during cognitive tasks
Higher cortical areas carry a wide range of sensory, cognitive and motor signals mixed in heterogeneous responses of single neurons tuned to multiple task variables. Dimensionality reduction methods that rely on correlations between neural activity and task variables leave unknown how heterogeneous responses arise from connectivity to drive behavior. We develop the latent circuit model, a dimensionality reduction approach in which task variables interact via low-dimensional recurrent connectivity to produce behavioral output. We apply the latent circuit inference to recurrent neural networks trained to perform a context-dependent decision-making task and find a suppression mechanism in which contextual representations inhibit irrelevant sensory responses. We validate this mechanism by confirming the behavioral effects of patterned connectivity perturbations predicted by the latent circuit model. We find similar suppression of irrelevant sensory responses in the prefrontal cortex of monkeys performing the same task. We show that incorporating causal interactions among task variables is critical for identifying behaviorally relevant computations from neural response data.
Grid-enhancing technologies for clean energy systems
Renewable energy source integration into energy systems can contribute to transmission congestion, which requires time-consuming and capital-intensive upgrades to address. Grid-enhancing technologies (GETs) can increase the capacity of grids with minimal investment, preventing congestion and curtailment of renewable energy. In this Review, we discuss the principles and uses of GETs, which use software and/or hardware to interpret real-time conditions to better use the existing capacity of grid assets. GETs include dynamic line ratings, dynamic transformer ratings, power flow controls, topology optimization, advanced conductor technologies, energy storage systems, and demand response. These GETs can enhance system performance individually, but the deployment of multiple GETs together would greatly increase their effect on the grid capacity and stability by removing multiple capacity bottlenecks in parallel. Infrastructure for real-time data acquisition, transmission and analysis is key to successfully deploying GETs but requires further development and commercialization for broader deployment.
The logarithmic memristor-based Bayesian machine
The demand for explainable and energy-efficient artificial intelligence (AI) systems for edge computing has led to growing interest in electronic systems dedicated to Bayesian inference. Traditional designs of such systems often rely on stochastic computing, which offers high energy efficiency but suffers from latency issues and struggles with low-probability values. Here, we introduce the logarithmic memristor-based Bayesian machine, an innovative design that leverages the unique properties of memristors and logarithmic computing as an alternative to stochastic computing. We present a prototype machine fabricated in a hybrid CMOS/hafnium-oxide memristor process. We validate the versatility and robustness of our system through experimental validation and extensive simulations in two distinct applications: gesture recognition and sleep stage classification. The logarithmic approach simplifies the computational model by converting multiplications into additions and enhances the handling of low-probability events, which are crucial in time-dependent tasks. Our results demonstrate that the logarithmic Bayesian machine achieves superior performance in terms of accuracy and energy efficiency compared to its stochastic counterpart, particularly in scenarios involving complex probabilistic models. This approach enables the development of energy-efficient and reliable AI systems for edge devices.
Intersect between brain mechanisms of conditioned threat, active avoidance, and reward
Active avoidance is a core behavior for human coping, and its excess is common across psychiatric diseases. The decision to actively avoid a threat is influenced by cost and reward. Yet, threat, avoidance, and reward have been studied in silos. We discuss behavioral and brain circuits of active avoidance and the interactions with fear and threat. In addition, we present a neural toggle switch model enabling fear-to-anxiety transition and approaching reward vs. avoiding harm decision. To fully comprehend how threat, active avoidance, and reward intersect, it is paramount to develop one shared experimental approach across phenomena and behaviors, which will ultimately allow us to better understand human behavior and pathology.
Spin polarised quantised transport via one-dimensional nanowire-graphene contacts
Graphene spintronics offers a promising route to achieve low power 2D electronics for next generation classical and quantum computation. As device length scales are reduced to the limit of the electron mean free path, the transport mechanism crosses over to the ballistic regime. However, ballistic transport has yet to be shown in a graphene spintronic device, a necessary step towards realising ballistic spintronics. Here, we report ballistic injection of spin polarised carriers via one-dimensional contacts between magnetic nanowires and a high mobility graphene channel. The nanowire-graphene interface defines an effective constriction that confines charge carriers over a length scale smaller than that of their mean free path. This is evidenced by the observation of quantised conductance through the contacts with no applied magnetic field and a transition into the quantum Hall regime with increasing field strength. These effects occur in the absence of any constriction in the graphene itself and occur across several devices with transmission probability in the range T = 0.08 − 0.30.
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