Sustainably addressing Africa’s antimicrobial pollution crisis
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Intercity personnel exchange is more effective than policy transplantation at reducing water pollution
Severe spatial disparities exist in water pollution and water governance. A popular solution is that lagging cities transplant policies from cities with successful experiences. However, environmental governance is more than policies. Merely copying policies from elsewhere may not generate intended effects. Here this research argues that intercity personnel exchange can be a more effective policy instrument than policy transplantation. We provide the first nationwide estimates in China of the effect of intercity exchange of city leaders on water pollution reduction. Using large-scale micro-level datasets on city leaders’ curriculum vitae, firm behaviors, patents and policy texts, we show that intercity exchange of city leaders leads to a 4.78–15.26% reduction in firm-level water pollution, which contributes to 39.45–57.98% of the national total water pollution reduction from 2006 to 2013. Exchanged city leaders facilitate the diffusion of governance experience across cities and the formulation of intercity cooperation. They are also more likely to initiate new policies to support industrial upgrading. Our findings highlight the importance and potential of intercity personnel exchange as a policy instrument for water governance in particular and green transition in general.
Discovery of new AMR drugs targeting modulators of antimicrobial activity using in vivo silkworm screening systems
Global concerns about drug-resistant bacteria have underscored the need for new antimicrobial drugs. Emerging strategies in drug discovery include considering the third factors that influence drug activity. These factors include host-derived elements, adjuvants, and drug combinations, which are crucial in regulating antimicrobial efficacy. Traditional in vivo assessments have relied on animal models to study drug absorption, distribution, metabolism, excretion, and toxicity (ADMET). Alternative models, such as silkworms, are being explored to overcome the ethical and financial barriers associated with mammalian models. The silkworm has been proven effective in evaluating ADMET and in highlighting the therapeutic potential enhanced by third factors. Host factors (either mammalian or non-mammalian) enhance the antimicrobial activity of antimicrobial agents such as lysocin E. Additionally, using d-cycloserine to potentiate vancomycin has successfully combated vancomycin-resistant infections in silkworms. Leveraging silkworms in drug discovery could establish a novel screening method incorporating interactions with third factors, whether host related or non-host-related, thus promising new pathways for identifying antimicrobial drugs with unique mechanisms of action.
Impact of transboundary water flows on quality-induced water pressure in China
Quality-induced water pressure (P) is gaining increased attention. With the flows of transboundary water, P can be transferred among upstream and downstream regions. Here, we quantified the magnitude of pollutant transmission, and assessed its impact on individual provinces in China. On the annual basis, P was mitigated in 61% of provinces for Chemical Oxygen Demand, 87% for Ammonia Nitrogen, and 84% for Total Phosphorus, while it was intensified for 77% for Total Nitrogen in 2021. The aggregated P were mitigated in 68% of provinces, while intensified in 32% provinces. Furthermore, the monthly assessment has found that the impact of transboundary water on P varies seasonally, generally alleviating in winter and exacerbating in summer. This fluctuation was attributed to the comparatively higher quality of transboundary inflows during winter relative to local water quality. This study provides a scientific foundation for effective water management and quality control.
Socially vulnerable communities face disproportionate exposure and susceptibility to U.S. wildfire and prescribed burn smoke
While air pollution from most U.S. sources has decreased, emissions from wildland fires have risen. Here, we use an integrated assessment model to estimate that wildfire and prescribed burn smoke caused $200 billion in health damages in 2017, associated with 20,000 premature deaths. Nearly half of this damage came from wildfires, predominantly in the West, with the remainder from prescribed burns, mostly in the Southeast. Our analysis reveals positive correlations between smoke exposure and various social vulnerability measures; however, when also considering smoke susceptibility, these disparities are systematically influenced by age. Senior citizens, who are disproportionately White, represented 16% of the population but incurred 75% of the damages. Nonetheless, within most age groups, Native American and Black communities experienced the greatest damages per capita. Our work highlights the extraordinary and disproportionate effects of the growing threat of fire smoke and calls for targeted, equitable policy solutions for a healthier future.
Urban inequality, the housing crisis and deteriorating water access in US cities
The housing unaffordability and cost-of-living crisis is affecting millions of people in US cities, yet the implications for urban dwellers’ well-being and social reproduction remain less clear. This Article presents a longitudinal analysis of household access to running water—a vital component of social infrastructure—in the 50 largest US cities since 1970. The results indicate that water access has worsened in an increasing number and typology of US cities since the 2008 global financial crash, disproportionately affecting households of color in 12 of the 15 largest cities. We provide evidence to suggest that a ‘reproductive squeeze’—systemic, compounding pressures on households’ capacity to reproduce themselves on a daily and societal basis—is forcing urban households into more precarious living arrangements, including housing without running water. We analyze the case study of Portland (Oregon) to illustrate the racialized nature of the reproductive squeeze under a housing crisis. Our insights reveal that plumbing poverty—a lack of household running water—is expanding in scope and severity to a broader array of US cities, raising doubts about equitable progress towards Sustainable Development Goals for clean water and sanitation for all (SDG 6) and sustainable cities (SDG 11) in an increasingly urbanized United States.
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