Adding blinatumomab to chemotherapy reduces recurrence risk in standard-risk paediatric B-ALL
Tag: Acute lymphocytic leukaemia
Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia
Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is an immature subtype of T-cell acute lymphoblastic leukemia (T-ALL) commonly show d…
Maternal weight during pregnancy and risk of childhood acute lymphoblastic leukemia in offspring
In addition to biological factors, maternal exposures during pregnancy can contribute to leukemogenesis in offspring. We conducted a population-bas…
Nelarabine in T-cell acute lymphoblastic leukemia: intracellular metabolism and molecular mode-of-action
T-cell acute lymphoblastic leukemia (T-ALL) patients often have a poor 5-year event-free survival. The only T-ALL specific drug in clinical practic…
Targeting osteoclasts for treatment of high-risk B-cell acute lymphoblastic leukemia
Results Using a murine BCR-ABL1+ B-ALL syngeneic model, we previously reported that osteoclasts are responsible for leukemia-induced bone loss [4]. In this study, we aimed…