Strategic re-engineering of antibiotics
Multidrug-resistant bacteria, especially those that defy even last-resort antibiotics, are causing a global health crisis fuelled by antibiotic ove…
Tag: Antibiotics
Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630
Clostridioides difficile infection (CDI) is the most common nosocomial infection in the US. CDI has become a growing concern due to C. di…
Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases
Acetohydroxyacid synthase (AHAS), exclusively present in microorganisms and plants, is a promising target for several herbicides due to its catalyt…
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii
Therapeutic options for carbapenem-resistant Acinetobacter baumannii (CA-AB) are quite limited. Cefiderocol, a novel siderophore cephalospor…
Evaluation of tirandamycins with selective activity against Enterococci in the silkworm infection model
In the course of screening for anti-enterococcal antibiotics from microbial resources, a new tirandamycin congener (1), together with four k…
Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii
Antibiotic-resistant bacteria pose a significant global health threat, particularly pathogens resistant to last-resort antibiotics, such as those l…
Protistan predation selects for antibiotic resistance in soil bacterial communities
Understanding how antibiotic resistance emerges and evolves in natural habitats is critical for predicting and mitigating antibiotic resistance in …
Prevalence and transmission risk of colistin and multidrug resistance in long-distance coastal aquaculture
Due to the wide use of antibiotics, intensive aquaculture farms have been recognized as a significant reservoir of antibiotic resistomes. Although …