Engineering bone/cartilage organoids: strategy, progress, and application
The concept and development of bone/cartilage organoids are rapidly gaining momentum, providing opportunities for both fundamental and translationa…
Tag: Bone quality and biomechanics
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cel…
Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness
Proteoglycans, key components of non-collagenous proteins in the bone matrix, attract water through their negatively charged glycosaminoglycan chai…
Skeletal interoception and prospective application in biomaterials for bone regeneration
Accumulating research has shed light on the significance of skeletal interoception, in maintaining physiological and metabolic homeostasis related …
Tree shrew as a new animal model for musculoskeletal disorders and aging
Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-rel…
Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections
Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional (3D) architecture of…
Role of macrophage in intervertebral disc degeneration
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immu…
Photothermal sensitive nanocomposite hydrogel for infectious bone defects
Infectious bone defects represent a substantial challenge in clinical practice, necessitating the deployment of advanced therapeutic strategies. Th…