Getting the right combination to break the epigenetic code
Rapid advances in the field of epigenetics have facilitated the development of novel therapeutics targeting epigenetic mechanisms that are hijacked…
Tag: Cancer epigenetics
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states
Mutations in cancer risk genes increase susceptibility, but not all carriers develop cancer. Indeed, while DNA mutations are necessary drivers of c…
Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules
To the Editor: Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the most common lymphomas, both exhibiting features of germinal center-derived B-cells (gcBCs).…
Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos
Prostate cancer (PC) is the commonest male visceral cancer, and second leading cause of cancer mortality in men in the Western world.
CALRins5-mediated clonal hematopoiesis causes severe hemolytic anemia in a female PGK1Ser320Asn carrier
Introduction Hereditary hemolytic anemias (HHA) are rare inherited red blood cell (RBC) disorders caused by genetic abnormalities (hemoglobino/membrano/enzymopathies), characterized by anemia due to premature RBC…