Tumour-agnostic kinase inhibitors
Protein kinases are crucial targets for cancer treatment as they orchestrate important signals for oncogenesis and are often aberrantly activated o…
Tag: Cancer genetics
Re-envisioning genetic predisposition to childhood and adolescent cancers
Although cancer is rare in children and adolescents, it remains a leading cause of death within this age range, and genetic predisposition is the m…
Implantation of engineered adipocytes suppresses tumor progression in cancer models
Tumors exhibit an increased ability to obtain and metabolize nutrients. Here, we implant engineered adipocytes that outcompete tumors for nutrients…
Evolutionary fingerprints of epithelial-to-mesenchymal transition
Mesenchymal plasticity has been extensively described in advanced epithelial cancers; however, its functional role in malignant progression is cont…
Two-hit mutation causes Wilms tumor in an individual with FBXW7-related neurodevelopmental syndrome
FBXW7 (F-box and WD-repeat domain-containing 7) is a tumor suppressor gene, and its germline variants have been causally linked to Wilms tum…
Novel MLH1 nonsense variant in a patient with suspected Lynch syndrome
Loss-of-function germline variants of MLH1 cause Lynch syndrome. Here, we present the case of a 43-year-old male patient diagnosed with ceca…
Genotypes and phenotypes of neurofibromatosis type 1 patients in Japan: A Hereditary Tumor Cohort Study
Neurofibromatosis type 1 (NF1) presents with a broad spectrum of clinical manifestations, including an increased risk of tumor development and hype…
High-resolution genetic analysis of whole APC gene deletions: a report of two cases and patient characteristics
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome caused by germline variants in the APC gene, leading to the developme…
Identification of the ferroptosisârelated gene signature and the associated regulation axis in lung cancer and rheumatoid arthritis
Patients with Rheumatoid arthritis (RA) have an elevated risk of lung cancer compared to the healthy population. However, there are few studies on …