Emerging clinical applications of single-cell RNA sequencing in oncology
Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of complex tissues both in health and in disease. Over the past decade,…
Tag: Cancer microenvironment
Enhancing immunotherapy with tumour-responsive nanomaterials
The targeted delivery of immunotherapies to tumours using tumour-responsive nanomaterials is a promising area of cancer research with the potential…
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME) that, among its many functions, enables the evasion of T cell-m…
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
Metabolic reprogramming of cancer cells and the tumour microenvironment are pivotal characteristics of cancers, and studying these processes offer …
Tumour hypoxia in driving genomic instability and tumour evolution
Intratumour hypoxia is a feature of all heterogenous solid tumours. Increased levels or subregions of tumour hypoxia are associated with an adverse…
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer
Mathematical modelling has proven to be a valuable tool in predicting the delivery and efficacy of molecular, antibody-based, nano and cellular the…
Defining a ‘cells to society’ research framework for appendiceal tumours
Tumours of the appendix — a vestigial digestive organ attached to the colon — are rare. Although we estimate that around 3,000 new appendiceal …
A multifunctional sensor for cell traction force, matrix remodeling and biomechanical assays in self-assembled 3D tissues in vitro
Cell–matrix interactions, mediated by cellular force and matrix remodeling, result in dynamic reciprocity that drives numerous biological process…
Spotiphy enables single-cell spatial whole transcriptomics across an entire section
Spatial transcriptomics (ST) has advanced our understanding of tissue regionalization by enabling the visualization of gene expression within whole…