The present and future of the Cancer Dependency Map
Despite tremendous progress in the past decade, the complex and heterogeneous nature of cancer complicates efforts to identify new therapies and th…
Tag: Cancer models
PDX models for functional precision oncology and discovery science
Precision oncology relies on detailed molecular analysis of how diverse tumours respond to various therapies, with the aim to optimize treatment ou…
Defining a ‘cells to society’ research framework for appendiceal tumours
Tumours of the appendix — a vestigial digestive organ attached to the colon — are rare. Although we estimate that around 3,000 new appendiceal …
Lymphatic collection and cell isolation from mouse models for multiomic profiling
Premetastatic cancer cells often spread from the primary lesion through the lymphatic vasculature and, clinically, the presence or absence of lymph…
Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid
Intestinal crypts harbour a specific microbiota but whether and how these bacteria regulate intestinal stem cells (ISCs) or influence colorectal ca…
Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer
Diet, microbiome, inflammation and host genetics have been linked to colorectal cancer development; however, it is not clear whether and how these …