Preclinical studies have shown that asparagine deprivation enhances T cell antitumour responses. Here we apply compassionate use of
Janus kinase (JAK) inhibitors provide limited depth and durability of response in myelofibrosis. We evaluated pelabresib—a bromodomain and extrat…
Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existence of alternative immunos…
The regressed arms of reversed replication forks exhibit structural similarities to one-ended double-stranded breaks and need to be protected again…
RAF protein kinases are major RAS effectors that function by phosphorylating MEK. Although all three RAF isoforms share a conserved RAS binding dom…
Measuring pharmacodynamics (PD)—the biochemical effects of drug dosing—and correlating them with therapeutic efficacy in animal models is cruci…