Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload
Sodium influx and overload are frequently observed in human tissue injuries. Whether sodium overload imposes a causative effect on necrotic cell de…
Tag: Cell death
PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer
The activation of ferroptosis has shown great potential for cancer therapy from an unconventional perspective, but revealing the mechanisms underly…
Cell-associated galectin 9 interacts with cytotoxic T cells confers resistance to tumor killing in nasopharyngeal carcinoma through autophagy activation
Immune effector cells, including cytotoxic T lymphocytes (CTLs) play essential roles in eliminating cancer cells. However, their functionality is o…
RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease
The emerging field of epitranscriptomics is reshaping our understanding of post-transcriptional gene regulation in inflammatory diseases. N<…
Cathepsin B prevents cell death by fragmentation and destruction of pathological amyloid fibrils
Amyloid fibrils cause organ and tissue dysfunction in numerous severe diseases. Despite the prevalence and severity of amyloidoses, there is still …
NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury
Brain endothelial cell (bEC) dysfunction is the main factor of blood-brain barrier (BBB) breakdown, which triggers a vicious cycle of aggravating t…
CeDaD—a novel assay for simultaneous tracking of cell death and division in a single population
The cell division cycle and the various forms of programmed cell death are interconnected. A prominent example is the tumor suppressor p53, which n…
Different types of cell death and their interactions in myocardial ischemia–reperfusion injury
Myocardial ischemia–reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow is resto…