Thirty years of NRF2: advances and therapeutic challenges
Over the last 30 years, NRF2 has evolved from being recognized as a transcription factor primarily involved in redox balance and detoxification t…
Tag: Cell signalling
Hereditary haemorrhagic telangiectasia
Hereditary haemorrhagic telangiectasia (HHT) is a vascular dysplasia inherited as an autosomal dominant trait and caused by loss-of-function pathog…
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Macrophages stimulated by lipopolysaccharide (LPS) generate mitochondria-derived reactive oxygen species (mtROS) that act as antimicrobial agents a…
Regulation of mammalian cellular metabolism by endogenous cyanide production
Small, gaseous molecules such as nitric oxide, carbon monoxide and hydrogen sulfide are produced as signalling molecules in mammalian cells. Here, …
DeltaC and DeltaD ligands play different roles in the segmentation clock dynamics
The vertebrate segmentation clock drives periodic somite segmentation during embryonic development. Her1 and Her7 clock proteins generate oscillato…
Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2–RAD51
The regressed arms of reversed replication forks exhibit structural similarities to one-ended double-stranded breaks and need to be protected again…
Orthogonalized human protease control of secreted signals
Synthetic circuits that regulate protein secretion in human cells could support cell-based therapies by enabling control over local environments. A…
Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance
RAF protein kinases are major RAS effectors that function by phosphorylating MEK. Although all three RAF isoforms share a conserved RAS binding dom…