STAT3 as a mediator of BCR-ABL1-independent resistance in chronic myeloid leukemia
Tag: Cell signalling
Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia
Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is an immature subtype of T-cell acute lymphoblastic leukemia (T-ALL) commonly show d…
STAT6 mutations compensate for CREBBP mutations and hyperactivate IL4/STAT6/RRAGD/mTOR signaling in follicular lymphoma
Activating mutations in STAT6 are common in Follicular Lymphoma (FL) and transformed FL and various other B cell lymphomas. Here, we report …
Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment
The ambiguity of etiology makes temporomandibular joint osteoarthritis (TMJOA) “difficult-to-treat”. Emerging evidence underscores the therapeu…
Does gastric bypass surgery change body weight set point?
The relatively stable body weight during adulthood is attributed to a homeostatic regulatory mechanism residing in the brain which uses feedback fr…
Bugs, guts and brains, and the regulation of food intake and body weight
The microbiota–gut–brain axis is currently being explored in many types of rodent models, including models of behavioral, neurodegenerative and…
Targeting the gut to treat obesity and its metabolic consequences: view from the Chair
The neurohumoral signaling systems of the gastrointestinal (GI) tract are considered the most significant of the peripheral inputs controlling both…
Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK
Phospholipase C β (PLCβ) is involved in diverse biological processes, including inflammatory responses and neurogenesis; however, its role in bon…
β-hydroxybutyrylation and O-GlcNAc modifications of STAT1 modulate antiviral defense in aging
Aging changes the protein activity status to affect the body’s functions. However, how aging regulates protein posttranslational modifications (P…