Smart molecular designs and applications of activatable organic photosensitizers
Photodynamic therapy (PDT) — which combines light, oxygen and photosensitizers (PS) to generate reactive oxygen species — has emerged as an eff…
Tag: Chemical tools
Data-driven federated learning in drug discovery with knowledge distillation
A main challenge for artificial intelligence in scientific research is ensuring access to sufficient, high-quality data for the development of impa…
Implications of frequent hitter E3 ligases in targeted protein degradation screens
Targeted protein degradation (TPD) offers a promising approach for chemical probe and drug discovery that uses small molecules or biologics to dire…
Mechanistic insights and approaches for beta cell regeneration
Diabetes is characterized by variable loss of insulin-producing beta cells, and new regenerative approaches to increasing the functional beta cell …
A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors
RNA methyltransferases (MTases) have recently become increasingly important in drug discovery. Yet, most frequently utilized RNA MTase assays are l…
Directed synthesis of N1/N3-histidine modified by 2-hydroxyethylthioethyl and identification in sulfur mustard-exposed plasma
Sulfur mustard (HD) alkylates biomolecules such as proteins, generating specific biomarkers. This study employs steric hindrance, electronic effect…