Interplay between periodontitis and chronic kidney disease
Periodontitis is a ubiquitous chronic inflammatory disease affecting the supporting tissues of the teeth and is a major cause of multiple tooth los…
Tag: Chronic inflammation
Trained immunity in chronic inflammatory diseases and cancer
A decade after the term ‘trained immunity’ (TRIM) was coined to reflect the long-lasting hyper-responsiveness of innate immune cells with an ep…
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
Regulatory T (Treg) cells are a specialized CD4+ T cell lineage with essential anti-inflammatory functions. Analysis of T
The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways
MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene exp…
Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain
Neuroinflammation, a significant contributor to various neurodegenerative diseases, is strongly associated with the aging process; however, to date…
A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis
Metabolic dysfunction-associated steatohepatitis (MASH) is associated with the activation of Kupffer cells (KCs) and hepatic stellate cells, at whi…