New Abelson interactor-1 (Abi-1)-driven mechanism of acquired drug resistance
Tag: Chronic myeloid leukaemia
Immunotherapy targeting a leader sequence cathepsin G-derived peptide
Myeloid azurophil granules provide a rich source of intracellular leukemia antigens. Cathepsin G (CG) is a serine protease that has higher expressi…
Challenges determining the best target duration of deep molecular response after which to attempt achieving therapy-free remission in chronic myeloid leukaemia
Eradication of leukaemia stem and progenitor cells Mathematical models of CML and TFR are often built on assumptions about haematopoiesis that may or may not…
CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells
Imatinib mesylate (IM) and other BCR-ABL tyrosine kinase inhibitors (BCR-ABLi) are the mainstay of chronic myelogenous leukemia (CML) treatment. Ho…