Endothelin receptor antagonists in chronic kidney disease
Endothelin-1 is a potent vasoconstrictor that has diverse physiological functions in the kidney, including in the regulation of blood flow and glom…
Tag: Clinical pharmacology
The TRPM7 chanzyme in smooth muscle cells drives abdominal aortic aneurysm in mice
Ionic signaling in smooth muscle cells (SMCs) is critical for vascular homeostasis. In this study, we untangled the role of the bifunctional TRPM7 …