High-resolution imaging of plasma membrane proteins
Tag: Cryoelectron microscopy
Structural mechanism underlying PHO1;H1-mediated phosphate transport in Arabidopsis
Arabidopsis PHOSPHATE 1 (AtPHO1) and its closest homologue AtPHO1;H1 are phosphate transporters that load phosphate into the xylem vessel fo…
The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation
The proper assembly and maturation of collagens necessitate the orchestrated hydroxylation and glycosylation of multiple lysyl residues in procolla…
Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase
Members of the Pol A family of DNA polymerases, found across all domains of life, utilize various strategies for DNA strand separation during repli…
Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis
Recent evidence shows elevated circulating long-chain ceramide levels predict atherosclerotic cardiovascular disease (ASCVD) independently of chole…
Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates
The spliceosome, a highly dynamic macromolecular assembly, catalyzes the precise removal of introns from pre-mRNAs. Recent studies have provided co…