Surveying the landscape of emerging osteoanabolic therapies
Tag: Drug discovery
Voltage-gated sodium channels in excitable cells as drug targets
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (Na
MYC in cancer: from undruggable target to clinical trials
MYC is among the most infamous oncogenes in cancer. A notable feature that distinguishes it from other common oncogenes is that its deregula…
Strategic re-engineering of antibiotics
Multidrug-resistant bacteria, especially those that defy even last-resort antibiotics, are causing a global health crisis fuelled by antibiotic ove…
An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive and mental health disorders
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel drugs approved for diabetes and obesity. They are acknowledged as a major scientific…
Efficacy and tolerability of neoadjuvant therapy with Talimogene laherparepvec in cutaneous basal cell carcinoma: a phase II trial (NeoBCC trial)
We present a single-arm, phase II, neoadjuvant trial with the oncolytic virus talimogene laherparepvec (T-VEC) in 18 patients with difficult-to-res…
Structure-activity relationship studies of ME1111, a novel antifungal agent for topical treatment of onychomycosis
Onychomycosis is a prevalent disease in many areas of the world, affecting approximately 5.5% of the global population. Among several subtypes of o…
The thiodiketopiperazine derivatives shovelmycin A–B and ansamycin derivative divergolide X from the cold-seep-derived Streptomyces olivaceus HDN22-001
Three new compounds including two thiodiketopiperazine derivatives shovelmycins A–B (1–2), and one ansamycin derivative divergoli…