Tag: Energy metabolism
Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is categorized into ~10% familial and ~90% sporadic cases. While familial ALS is caused by mutations in many ge…
Recommendations for mitochondria transfer and transplantation nomenclature and characterization
Intercellular mitochondria transfer is an evolutionarily conserved process in which one cell delivers some of their mitochondria to another cell in…
VDAC2 and Bak scarcity in liver mitochondria enables targeting hepatocarcinoma while sparing hepatocytes
Differences between normal tissues and invading tumors that allow tumor targeting while saving normal tissue are much sought after. Here we show th…
An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly
The correct sorting of nascent ribosomal proteins from the cytoplasm to the nucleus or to mitochondria for ribosome production poses a logistical c…