Defining a ‘cells to society’ research framework for appendiceal tumours
Tumours of the appendix — a vestigial digestive organ attached to the colon — are rare. Although we estimate that around 3,000 new appendiceal …
Tag: Gastrointestinal cancer
Evolutionary fingerprints of epithelial-to-mesenchymal transition
Mesenchymal plasticity has been extensively described in advanced epithelial cancers; however, its functional role in malignant progression is cont…
High-resolution genetic analysis of whole APC gene deletions: a report of two cases and patient characteristics
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome caused by germline variants in the APC gene, leading to the developme…
BRD9 promotes the progression of gallbladder cancer via CST1 upregulation and interaction with FOXP1 through the PI3K/AKT pathway and represents a therapeutic target
Gallbladder cancer (GBC) is highly aggressive and has poor prognosis, with most patients only diagnosed at an advanced stage. Furthermore, treatmen…
Sequential STING and CD40 agonism drives massive expansion of tumor-specific T cells in liposomal peptide vaccines
The clinical use of cancer vaccines is hampered by the low magnitude of induced T-cell responses and the need for repetitive antigen stimulation. H…
Integrated proteogenomic characterization of ampullary adenocarcinoma
Ampullary adenocarcinoma (AMPAC) is a rare and heterogeneous malignancy. Here we performed a comprehensive proteogenomic analysis of 198 samples fr…
Significance of homologous recombinant deficiency as a biomarker for drug sensitivity in colorectal cancer
Colorectal cancer (CRC) is a substantial global health concern due to its limited treatment options, especially for oxaliplatin (L-OHP) regimen res…