Advancing clinical genomics with Middle Eastern and South Asian pangenomes
Migration, trade and climate The Middle East and South Asia form a contiguous landmass, historically serving as a bridge for migration, trade and cultural exchange,…
Tag: Genetic variation
Evolution, genetic diversity, and health
Human genetic diversity in today’s world has been shaped by evolutionary history, demographic shifts and environmental exposures, influencing com…
Genetic analysis of a Yayoi individual from the Doigahama site provides insights into the origins of immigrants to the Japanese Archipelago
Mainland Japanese have been recognized as having dual ancestry, originating from indigenous Jomon people and immigrants from continental East Euras…
High-coverage whole-genome sequencing of a Jakun individual from the “Orang Asli” Proto-Malay subtribe from Peninsular Malaysia
Jakun, a Proto-Malay subtribe from Peninsular Malaysia, is believed to have inhabited the Malay Archipelago during the period of agricultural expan…
Accelerated differentiation of neo-W nuclear-encoded mitochondrial genes between two climate-associated bird lineages signals potential co-evolution with mitogenomes
There is considerable evidence for mitochondrial-nuclear co-adaptation as a key evolutionary driver. Hypotheses regarding the roles of sex-linkage …
Influence of geographic isolation and the environment on gene flow among phenotypically diverse lizards
Lizards in the genus Anolis comprise hundreds of species that display a wide range of phenotypic variation closely related to their environm…
Estimation of Jacquard’s genetic identity coefficients with bi-allelic variants by constrained least-squares
The Jacquard genetic identity coefficients are of fundamental importance in relatedness research. We address the estimation of these coefficients a…
Genome-wide local ancestry and the functional consequences of admixture in African and European cattle populations
Bos taurus (taurine) and Bos indicus (indicine) cattle diverged at least 150,000 years ago and, since that time, substantial genomic …
Kinship clustering within an ecologically diverse killer whale metapopulation
Metapopulation dynamics can be shaped by foraging ecology, and thus be sensitive to shifts in prey availability. Genotyping 204 North Atlantic kill…